Oxiracetam 100mg/ml, 30ml

Description

Oxiracetam – 100mg/mL (30mL) – A Potent Water-Soluble Racetam for Cognitive and Neurochemical Studies

Category: Nootropic Research Compounds / Racetams / Cholinergic & Neuroenergetic Research

Disclaimer:
ATTENTION: ELITEBIOGENIX.COM PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH AND IN-VITRO STUDIES ONLY. All information presented on this site is for educational and research purposes related to scientific investigation. These products are strictly not for human or veterinary use, consumption, or diagnostic applications. They are not pharmaceuticals, food additives, or dietary supplements. By purchasing from EliteBiogenix.com, you acknowledge and affirm that you are a qualified researcher operating in a controlled laboratory environment. You must adhere to all applicable local, state, and federal laws and regulations regarding the handling and use of research chemicals. Handle all materials with appropriate personal protective equipment (PPE) and under laboratory safety protocols.

Enhancing Neuroenergetics and Synaptic Transmission: A Research Guide to Oxiracetam

Welcome, esteemed researchers, to EliteBiogenix’s detailed examination of a highly potent, water-soluble racetam compound: Oxiracetam. This product is a high-purity, liquid-formulation provided at a concentration of 100mg/mL within a 30mL aqueous vehicle, ideal for precise volumetric dosing in laboratory settings. 4-hydroxy-2-oxo-1-pyrrolidineacetamide is a molecule of significant interest due to its proposed dual mechanisms of action, impacting both cholinergic neurotransmission and cerebral energy metabolism. This product description serves as a foundational research primer to guide your experimental design in neuropharmacology, cognitive science, and mitochondrial function.

Section 1: The Scientific Basis of Oxiracetam’s Mechanism of Action

Oxiracetam’s research value lies in its potential to modulate key cognitive systems with greater potency than its predecessor, Piracetam. Its mechanisms are central to neuronal communication and energy utilization.

1. Modulation of Glutamatergic and Cholinergic Systems: Oxiracetam is believed to positively influence excitatory neurotransmission, particularly at glutamate receptors. It may enhance the function of AMPA-type glutamate receptors, facilitating synaptic plasticity, which is the cellular foundation of learning and memory. Furthermore, a significant body of research points to its ability to modulate the cholinergic system. Oxiracetam has been shown to increase the synthesis and release of acetylcholine (ACh) in relevant brain regions like the hippocampus and cortex, and may also influence cholinergic receptor density. This dual action on the brain’s primary excitatory and learning/memory systems makes it a valuable research tool.

2. Influence on Neuroenergetics and Brain Metabolism: A distinguishing hypothesis regarding Oxiracetam is its potential impact on cerebral energy metabolism. Research suggests it may enhance the activity of key enzymes in the Krebs cycle and the electron transport chain, potentially leading to increased production of adenosine triphosphate (ATP). In a neuron, ATP is required for virtually every energy-intensive process, including maintaining ion gradients, vesicle recycling, and synthesizing neurotransmitters. By supporting mitochondrial efficiency, Oxiracetam may provide the metabolic foundation for enhanced cognitive function and neuronal resilience.

3. Interaction with the Nootropic Receptor Site: While not fully elucidated, racetams like Oxiracetam are thought to interact with a specific, yet-to-be-fully-characterized “nootropic receptor” in the brain. This interaction is believed to modulate neuronal membrane fluidity, which can affect receptor function, enzyme activity, and signal transduction efficiency.

4. Potential Neuroprotective Properties: Through its support of mitochondrial function and cholinergic transmission, Oxiracetam may offer protective benefits in models of neuronal stress, hypoxia, and excitotoxicity. Research in this area focuses on its ability to maintain cellular integrity under challenging conditions.

The combination of neurotransmitter modulation and metabolic support makes Oxiracetam a versatile compound for researchers investigating the integrated biology of cognitive processes and neuronal health.

Section 2: Key Research Applications for Oxiracetam

Our 30mL vial of Liquid Oxiracetam (100mg/mL) is designed for controlled in-vitro and ex-vivo research applications. The following sections outline primary research domains, supported by peer-reviewed studies.

2.1 Investigating Cognitive Enhancement and Memory Formation

Oxiracetam has been extensively studied in animal models of learning and memory, demonstrating efficacy in reversing cognitive deficits and enhancing performance in healthy models.

• Relevant Study: *Mondadori, C., Ducret, T., & Borkowski, J. (1992). The effects of oxiracetam (ISF 2522) on memory and brain biochemistry in mice. Pharmacology, Biochemistry and Behavior, 41(2), 325-330.**

  • PubMed Link: https://pubmed.ncbi.nlm.nih.gov/1349768/

  • Focus of Research: This preclinical study investigated the effects of Oxiracetam on memory retention in mice and correlated these effects with changes in brain biochemistry.

  • Key Findings: The research demonstrated that Oxiracetam prevented scopolamine-induced amnesia in a step-through passive avoidance test. Biochemically, it was found to increase the incorporation of choline into acetylcholine in the hippocampus and cortex, providing a direct mechanistic link to its procognitive effects.

  • Research Implication: Researchers can use our Oxiracetam in primary hippocampal or cortical neuronal cultures. Experiments can involve co-administration with cholinergic antagonists like scopolamine to study Oxiracetam’s ability to restore synaptic plasticity (e.g., Long-Term Potentiation in brain slices) or enhance markers of cholinergic function, such as choline acetyltransferase (ChAT) activity or ACh release measured via ELISA.

  • Estimated Compound Usage for In-Vitro Replication: Effective concentrations in cell culture and brain slice models often range from 10-100 µM. For a 10 mL culture at 100 µM, this would require approximately 0.17 mg of Oxiracetam. Our 30mL vial at 100mg/mL provides a total of 3000 mg, allowing for extensive, long-term studies, including chronic exposure models and detailed dose-response curves.

2.2 Research on Brain Energy Metabolism and Mitochondrial Function

The hypothesis that Oxiracetam enhances cognitive function through improved brain bioenergetics is a key area of scientific inquiry.

• Relevant Study: *Nakahiro, M., Fukuhara, K., & (1992). Oxiracetam increases the activity of pyruvate dehydrogenase complex in cultured brain cells. Japanese Journal of Pharmacology, 58(2), 235-237.*

  • PubMed Link: https://pubmed.ncbi.nlm.nih.gov/1583710/

  • Focus of Research: This in-vitro study directly examined the effects of Oxiracetam on a key metabolic enzyme, pyruvate dehydrogenase complex (PDH), in cultured brain cells.

  • Key Findings: The study found that Oxiracetam treatment significantly increased the activity of PDH. This enzyme is critical for converting pyruvate into acetyl-CoA, which then enters the Krebs cycle to drive ATP production. This provides direct evidence for Oxiracetam’s role in enhancing mitochondrial energy metabolism.

  • Research Implication: Researchers can use our Oxiracetam in neuronal cell lines (e.g., SH-SY5Y) or primary astrocytes to measure its impact on mitochondrial function. Key assays include the MTT assay (as a proxy for metabolic activity), direct measurement of cellular ATP levels using a luciferase-based assay, and analysis of mitochondrial membrane potential using fluorescent dyes like JC-1 or TMRM.

  • Estimated Compound Usage for In-Vitro Replication: Metabolic studies often require sustained exposure over 24-72 hours to observe changes in enzyme activity and energy production. The large volume and high concentration of our product are ideal for these longer-duration experiments, where media may need to be replaced or supplemented multiple times.

2.3 Exploring Effects on Age-Related and Chemically-Induced Cognitive Deficits

Oxiracetam’s multi-target action makes it a candidate for research into various models of cognitive impairment.

• Relevant Study: *Banfi, S., & Dorigotti, L. (1984). Experimental behavioral studies with oxiracetam on different types of chronic cerebral impairment. Clinical Neuropharmacology, 7 Suppl 1, S768-S769.*

  • PubMed Link: https://pubmed.ncbi.nlm.nih.gov/6529873/

  • Focus of Research: This study reviewed and presented data on the effects of Oxiracetam in animal models of chronic cerebral impairment, including aging and brain lesion models.

  • Key Findings: The compiled evidence indicated that Oxiracetam could improve learning and memory performance in aged rodents and in those with brain lesions, suggesting its potential to ameliorate deficits associated with neuronal dysfunction and decline.

  • Research Implication: Researchers can use our Oxiracetam in in-vitro models of brain aging, such as senescent neuronal cultures or models of oxidative stress (e.g., treatment with hydrogen peroxide). Endpoints can include cell viability, markers of oxidative damage (e.g., lipid peroxidation, protein carbonylation), and the expression of synaptic proteins.

  • Estimated Compound Usage for In-Vitro Replication: Aging and stress models often require pre-treatment and continuous exposure. The 30mL volume ensures researchers can maintain consistent concentrations over the necessary duration for these chronic models.

2.4 Studies on Focus and Cognitive Processing

Beyond memory, Oxiracetam is researched for its potential to enhance attention and information processing speed.

• Research Application: In-vitro models that measure neuronal network activity, such as microelectrode array (MEA) systems, can be used to study the effects of Oxiracetam on the firing patterns, synchrony, and burst activity of neuronal networks. This can provide insights into how the compound might influence higher-order cognitive functions at a network level.

• Experimental Design: Researchers can treat cultured neuronal networks on MEA chips with our Oxiracetam and record changes in network activity parameters before and after treatment, comparing them to vehicle controls.

Section 3: Synergistic Research: Oxiracetam and Other Compounds

A sophisticated research approach often involves studying combinations of compounds to explore synergistic effects.

• With Cholinergic Compounds (e.g., Alpha GPC): This is a classic research paradigm. The hypothesis is that Oxiracetam increases the demand for and release of acetylcholine, while a choline donor like Alpha GPC provides the essential precursor. In-vitro research can test if this combination leads to a synergistic increase in ACh output or enhanced neuronal metabolic activity compared to either compound alone.

• With Other Racetams: Research can be designed to compare the potency and efficacy of Oxiracetam with other racetams (e.g., Aniracetam, Piracetam) in the same experimental model, providing valuable comparative pharmacological data, particularly regarding their effects on metabolism versus receptor modulation.

• With Neuroprotective Agents: Studies could investigate if Oxiracetam can enhance the effects of other neuroprotective agents, such as Citicoline or CoQ10, in models of metabolic stress, by providing complementary support for energy production and membrane integrity.

Section 4: EliteBiogenix Quality and Specifications

Product Specification:

• Compound Name: Oxiracetam (4-hydroxy-2-oxo-1-pyrrolidineacetamide)

• Concentration: 100mg/mL

• Volume: 30mL

• Vehicle: Proprietary aqueous research solution

• Purity: ≥98% (HPLC Verified)

• Form: Clear liquid solution

• Storage: Store at room temperature (20-25°C). Protect from light. Ensure the cap is tightly sealed.

• Handling: Use within a laminar flow hood for sterile applications. The liquid format is ready for precise volumetric dosing.

Why Choose EliteBiogenix for Your Oxiracetam Research?

• Superior Water-Soluble Formulation: Our Oxiracetam is provided in a stable, ready-to-use aqueous vehicle. This eliminates the solubility challenges sometimes associated with research compounds, ensuring rapid and homogeneous distribution in cell culture media and aqueous buffers.

• Uncompromising Purity: Every batch is independently verified via HPLC to ensure you are working with a high-purity compound, free from significant contaminants or degradation products.

• Precision and Consistency: The liquid format allows for highly precise, volumetric dosing using standard laboratory pipettes, ensuring consistency and reproducibility across your experiments.

• Research-Focused: We cater exclusively to the scientific community. Our products and documentation are designed for laboratory use, providing the data and quality required for rigorous scientific investigation.

Section 5: Conclusion and Research Direction

This 30mL vial of Liquid Oxiracetam (100mg/mL) from EliteBiogenix provides a versatile and potent tool for advanced research in neuroscience and cell biology. Its dual potential to support both neurochemical transmission and cerebral energy metabolism makes it an invaluable compound for dissecting the complex mechanisms of cognition and neuronal resilience. Research with Oxiracetam continues to illuminate the critical link between metabolic health and cognitive function.

We are committed to supporting your important work with the highest quality, most convenient research materials available.

Order your vial of Liquid Oxiracetam today and advance your research into neuroenergetics and cognitive function.

Remember: EliteBiogenix.com products are for laboratory research use only. Not for human or veterinary consumption.