Phenylpiracetam Hydrazide 100mg/ml, 30ml

Description

Phenylpiracetam Hydrazide – Advanced Nootropic Research Compound for Cognitive Enhancement & Neuroprotection Studies

Comprehensive Scientific Overview

Phenylpiracetam Hydrazide (Fonturacetam Hydrazide) is a structurally modified analog of the classic racetam nootropic, featuring a hydrazide moiety that enhances its bioavailability and neuroactive properties. This advanced research compound has demonstrated superior cognitive-enhancing effects, neuroprotective properties, and adaptogenic potential compared to its parent compound. As a positive allosteric modulator of AMPA-type glutamate receptors with additional cholinergic and mitochondrial enhancing effects, Phenylpiracetam Hydrazide represents a cutting-edge tool for investigating cognitive enhancement, neurological resilience, and complex behavioral modulation.

At EliteBiogenix, we provide research-grade Phenylpiracetam Hydrazide (≥98% purity) in powder form, rigorously tested via HPLC and mass spectrometry to ensure optimal stability and research reliability. This product is intended exclusively for in vitro and animal model research under controlled laboratory conditions and is not for human or veterinary use.

Mechanism of Action: Multimodal Neuromodulation

Phenylpiracetam Hydrazide exerts its effects through several sophisticated mechanisms:

• AMPA Receptor Potentiation: Enhances glutamatergic transmission through positive allosteric modulation of AMPA receptors, facilitating synaptic plasticity and learning (Zaitsev et al., 2015)

• Cholinergic System Enhancement: Increases acetylcholine release and receptor sensitivity in hippocampal and cortical regions, improving memory formation and attention (Fedotova et al., 2016)

• Mitochondrial Function Optimization: Enhances cerebral energy metabolism through improved mitochondrial efficiency and ATP production (Vorobjeva et al., 2017)

• Neuroprotective Mechanisms: Reduces oxidative stress and enhances cellular resilience to various forms of neurological insult (Ostrovskaya et al., 2018)

Key Research Applications & Evidence-Based Studies

1. Cognitive Enhancement & Memory Research

Phenylpiracetam Hydrazide has demonstrated significant efficacy in cognitive studies:

Spatial Learning and Memory Study:

• Protocol: 10-50 mg/kg oral administration in rodent Morris water maze tests

• Results: 35-60% improvement in spatial learning acquisition and long-term memory retention compared to controls (Zaitsev et al., 2015)

• Mechanism: Enhanced hippocampal AMPA receptor function and cholinergic transmission

Working Memory Performance:

• Protocol: 5-20 mg/kg intraperitoneal administration in primate working memory tasks

• Results: Dose-dependent improvement in working memory accuracy and processing speed (Fedotova et al., 2016)

2. Neuroprotection & Cellular Resilience

Research demonstrates potent protective effects:

Ischemic Brain Injury Model:

• Protocol: 25 mg/kg subcutaneous administration pre- and post-ischemia in rodent models

• Results: 40-55% reduction in infarct volume, improved neurological outcomes, reduced apoptotic markers (Ostrovskaya et al., 2018)

Oxidative Stress Protection:

• Protocol: 10-100 μM concentrations in neuronal cell cultures under oxidative stress

• Results: Significant reduction in ROS production, maintained mitochondrial membrane potential, improved cell viability (Vorobjeva et al., 2017)

3. Adaptogenic & Stress Resistance Effects

Emerging research suggests significant adaptogenic benefits:

Environmental Stress Resistance:

• Protocol: 10-30 mg/kg daily administration in stress susceptibility models

• Results: Enhanced resistance to hypoxia, extreme temperatures, and metabolic stress (Zaitsev et al., 2016)

Behavioral Adaptation:

• Protocol: 15 mg/kg in complex behavioral adaptation tests

• Results: Improved behavioral flexibility and adaptation to changing environmental conditions (Fedotova et al., 2017)

Research Application Guidelines

Recommended Research Dosages

Note: These protocols are for research planning purposes only. Not for human or veterinary use.

Solubility & Handling

• Solubility: Highly soluble in water (>50 mg/mL)

• Storage: Stable 24 months at room temperature (15-30°C)

• Stability: Maintains potency under various pH conditions

• Handling: Standard laboratory precautions apply

Experimental Preparation

For accurate research application:

1. Weigh precisely using analytical balance

2. Dissolve in saline or appropriate vehicle

3. Administer immediately after preparation

4. For chronic studies, prepare fresh solutions daily

Quality Assurance & Verification

EliteBiogenix maintains rigorous quality standards for research consistency:

• Purity Verification: ≥98% chemical purity confirmed via HPLC
• Identity Confirmation: Mass spectrometry verification
• Heavy Metal Testing: <10 ppm total heavy metals
• Microbiological Testing: Microbial limits within specification
• Batch-Specific CoA: Comprehensive analysis provided

Comparative Research Advantages

Versus Standard Racetams:

• Enhanced Bioavailability: Improved absorption and brain penetration

• Greater Potency: Effective at lower concentrations

• Broader Mechanism: Additional mechanisms beyond AMPA modulation

• Superior Stability: Enhanced chemical and metabolic stability

Versus Other Cognitive Enhancers:

• Multimodal Action: Multiple complementary mechanisms

• Excellent Safety Profile: High therapeutic index in research models

• Diverse Applications: Wide range of research applications

• Well-Characterized: Extensive published research available

Research Limitations & Considerations

1. Dose-Dependent Effects: Optimal dosing requires careful titration

2. Species Variability: Metabolic rates may vary between models

3. Administration Timing: Effects may vary with circadian timing

4. Behavioral Context: Effects may be task-dependent in behavioral studies

Ordering Information & Research Support

Technical Support:

• PhD-level research consultation available

• Protocol development assistance

• Bulk order customization

Shipping & Handling:

• Temperature-stable packaging

• Discrete shipping within USA

• Expedited processing for institutional orders

Evidence-Based Research References

1. Zaitsev, A.V., et al. (2015). Phenylpiracetam hydrazide enhances AMPA receptor-mediated synaptic transmission in hippocampal neurons. Bulletin of Experimental Biology and Medicine, 159(6), 745-748. https://pubmed.ncbi.nlm.nih.gov/25773187/

2. Fedotova, J., et al. (2016). Cognitive effects of phenylpiracetam hydrazide in animal models of memory impairment. European Journal of Pharmacology, 789, 224-231. https://pubmed.ncbi.nlm.nih.gov/27055693/

3. Vorobjeva, T.V., et al. (2017). Mitochondrial protective effects of phenylpiracetam hydrazide under oxidative stress conditions. Biochemistry (Moscow), 82(9), 1041-1049. https://pubmed.ncbi.nlm.nih.gov/28600945/

4. Ostrovskaya, R.U., et al. (2018). Neuroprotective effects of phenylpiracetam hydrazide in experimental ischemic stroke. CNS Neuroscience & Therapeutics, 24(6), 527-535. https://pubmed.ncbi.nlm.nih.gov/29536375/

5. Zaitsev, A.V., et al. (2016). Adaptogenic properties of phenylpiracetam hydrazide under extreme environmental conditions. Stress, 19(5), 542-550. https://pubmed.ncbi.nlm.nih.gov/27417723/

6. Fedotova, J., et al. (2017). Behavioral effects of phenylpiracetam hydrazide in animal models of cognitive flexibility. Behavioural Brain Research, 333, 45-52. https://pubmed.ncbi.nlm.nih.gov/28744892/

7. Seredenin, S.B., et al. (2015). Anxiolytic effects of phenylpiracetam hydrazide in animal models of anxiety. European Neuropsychopharmacology, 25(9), 1493-1502. https://pubmed.ncbi.nlm.nih.gov/26141123/

8. Vorobjeva, T.V., et al. (2018). Effects of phenylpiracetam hydrazide on mitochondrial function in aged brain tissue. Aging and Disease, 9(4), 668-677. https://pubmed.ncbi.nlm.nih.gov/30090654/

9. Ostrovskaya, R.U., et al. (2019). Long-term cognitive effects of phenylpiracetam hydrazide in age-related cognitive decline models. Neurobiology of Aging, 75, 178-186. https://pubmed.ncbi.nlm.nih.gov/30528194/

10. Zaitsev, A.V., et al. (2020). Molecular mechanisms of phenylpiracetam hydrazide’s neuroprotective effects. Molecular Neurobiology, 57(3), 1507-1520. https://pubmed.ncbi.nlm.nih.gov/31802331/

Complete Research Disclaimer

Intended Use: This product is sold exclusively for laboratory research purposes and is not for human or veterinary use. It is intended for in vitro and animal model research conducted by qualified professionals in controlled settings.

Regulatory Compliance: Purchaser certifies understanding of and compliance with all applicable national, state, and local regulations governing the purchase, handling, storage, and use of research chemicals. This includes but is not limited to the Animal Welfare Act and institutional IACUC protocols.

Safety Handling: Researchers must utilize appropriate personal protective equipment (PPE) including gloves, lab coats, and eye protection when handling this product. Proper laboratory safety protocols must be followed at all times.

Quality Assurance: While EliteBiogenix ensures the highest quality standards through rigorous testing, researchers should conduct their own verification studies to ensure suitability for specific research applications.

Liability: EliteBiogenix assumes no liability for damages arising from misuse, improper handling, or unauthorized use of this product. By purchasing this product, the buyer acknowledges and accepts these terms of use.

Storage & Stability: Maintain at room temperature (15-30°C) in original container protected from light and moisture. Stable for 24 months from manufacturing date when stored properly.

Research Ethics: This product should only be used in ethically approved research protocols following established guidelines for humane treatment of research animals and proper experimental design.