Description

Laboratory-Grade DMSO Solution (60ml) – EliteBiogenix.com

High-Purity Dimethyl Sulfoxide for Advanced Solvent & Transdermal Research Applications

Welcome to EliteBiogenix, your premier source for high-purity, research-grade biochemicals. Our Laboratory-Grade Dimethyl Sulfoxide Solution (99.9% Anhydrous) is an essential tool for in vitro and preclinical research, specifically formulated to serve as a superior solvent and transdermal carrier for a wide array of research compounds. This 60ml bottle of high-purity Dimethyl Sulfoxide is an indispensable component in the modern laboratory for studies involving cellular permeability, compound solubility, and topical application protocols.

This product is designed and manufactured exclusively for scientific investigation in controlled laboratory environments. It is intended for research purposes only and is not for human or veterinary consumption, diagnosis, or treatment of any medical condition.

CRITICAL NOTICE: This product is sold strictly for research purposes only. Dimethyl Sulfoxide is a potent solvent that rapidly penetrates skin and membranes and can carry other compounds with it. It is to be used solely by qualified researchers in controlled laboratory settings with appropriate personal protective equipment (PPE). By purchasing this product, you confirm that you are aware of its properties and intended use and will adhere to all applicable local, state, and federal regulations governing the use of research chemicals.

Our Dimethyl Sulfoxide is synthesized to the highest standards and undergoes rigorous third-party gas chromatography (GC) analysis to ensure ≥99.9% purity and anhydrous quality, providing unmatched reliability and consistency for your most sensitive scientific studies.

Research Focus: The Versatile Role of DMSO in the Laboratory

Dimethyl Sulfoxide is one of the most significant and versatile solvents in scientific research. Its unique chemical properties make it invaluable for a multitude of applications:

• Powerful Polar Aprotic Solvent: Excellently dissolves a wide range of polar and nonpolar compounds, including many peptides, synthetic organic molecules, and other research chemicals that are poorly soluble in water.

• Cryopreservation: Widely used in cell culture to protect cells from ice crystal formation during the freezing process, ensuring viability upon thawing.

• Transdermal Carrier: Its ability to rapidly penetrate biological membranes makes it a premier subject for research into topical and transdermal delivery systems for other active compounds.

• Cell Permeability Studies: Used to introduce membrane-impermeable molecules into cells for intracellular studies.

• Anti-Inflammatory & Antioxidant Research: DMSO itself has been studied for its intrinsic radical-scavenging and anti-inflammatory properties in various in vitro and preclinical models.

This 60ml solution provides researchers with a reliable, high-purity source of DMSO for these critical applications and more.

1. DMSO as a Superior Laboratory Solvent

Mechanism of Action:
Dimethyl Sulfoxide is a polar aprotic solvent with a highly polar domain and two nonpolar methyl groups, allowing it to dissolve a vast spectrum of hydrophilic and hydrophobic compounds. Its ability to form hydrogen bonds while lacking an acidic proton makes it ideal for dissolving compounds that are challenging to bring into solution with aqueous buffers alone.

Research Applications & Key Studies:

• Solubilization of Research Compounds: Dimethyl Sulfoxide is the universal standard solvent for creating stock solutions of countless research peptides, small molecules, and other biochemicals due to its high solvating power.

  • Context: This is a fundamental, well-established practice in thousands of laboratories worldwide. It is standard protocol to first dissolve a compound in 100% DMSO before diluting it to the final working concentration in an aqueous buffer (e.g., often keeping final DMSO concentrations <0.1-1% in cell culture to avoid cytotoxicity).

• Cryopreservation of Cell Lines: Dimethyl Sulfoxide is a critical cryoprotectant, preventing the formation of intracellular ice crystals that would lyse cells during freezing.

  • Study: Mechanisms of cryoprotection in DMSO

  • Research Concentration: Typically used at a concentration of 5-10% (v/v) in cell culture media containing fetal bovine serum for freezing cells.

Suggested Research Protocols:

• Stock Solution Preparation: Compounds are often dissolved in 100% DMSO at concentrations of 10-100 mM.

• Working Solution Preparation: The stock solution is then diluted in saline or cell culture media so that the final DMSO concentration is ≤0.1% for sensitive cell lines or ≤1% for more robust assays.

• Cryopreservation: A 10% Dimethyl Sulfoxide / 90% FBS solution is a standard cryopreservation medium.

Best for: Creating stable stock solutions of research peptides, SARMs, and other small molecules; cryopreserving eukaryotic cell lines.

2. DMSO as a Transdermal Penetration Enhancer

Mechanism of Action:
Dimethyl Sulfoxide’s efficacy as a transdermal carrier is due to several actions:

• Interaction with Lipid Bilayers: It disrupts the structure of the stratum corneum, the outermost layer of the skin, by extracting lipids and altering protein confirmation, thereby reducing barrier function.

• Carrier Effect: Molecules dissolved in Dimethyl Sulfoxide are carried along as the Dimethyl Sulfoxide molecules themselves rapidly diffuse through membranes and into systemic circulation.

• Increased Hydration: It draws water into the skin, which can also enhance the permeability of other compounds.

Research Applications & Key Studies:

• Enhancing Topical Drug Delivery: Studies have extensively documented DMSO’s ability to significantly increase the skin permeability of various compounds.

  • Study: Mechanism of action of DMSO as a penetration enhancer

  • Research Concentration: Studies often use Dimethyl Sulfoxide at concentrations between 50-70% (v/v) in aqueous solutions as a vehicle for topical application of other compounds in preclinical models.

• Research on Localized Effects: Dimethyl Sulfoxide can be used to facilitate the delivery of compounds intended to have a localized effect in dermal or subcutaneous tissue research models.

Suggested Research Protocols:

• Transdermal Vehicle: A 50-70% Dimethyl Sulfoxide solution in deionized water or saline is a common vehicle for dissolving compounds for topical application in preclinical dermatological research.

• Important Note: The concentration of Dimethyl Sulfoxide and the compound being delivered must be carefully optimized to avoid skin irritation or systemic toxicity in animal models.

Best for: Preclinical research on transdermal delivery systems, topical application studies for localized effects, and enhancing the permeability of other research compounds.

3. Intrinsic Biological Properties of DMSO

Beyond its solvent and carrier functions, Dimethyl Sulfoxide itself has been a subject of research for its own biological properties.

Mechanism of Action:

• Free Radical Scavenging: Dimethyl Sulfoxide is a potent hydroxyl radical scavenger, converting these highly damaging radicals into less reactive species.

• Anti-Inflammation: It can inhibit inflammatory processes by suppressing the activation of NF-κB, a key transcription factor in the inflammatory response.

• Membrane Stabilization: It can stabilize neuronal membranes and has been researched in contexts of acute trauma.

Research Applications & Key Studies:

• Reduction of Oxidative Stress: Research has shown Dimethyl Sulfoxide’s effectiveness in scavenging free radicals in various in vitro models of oxidative damage.

  • Study: Hydroxyl radical scavenging by DMSO

  • Research Concentration: In vitro studies often use DMSO at concentrations of 0.5% to 1% (v/v) to demonstrate radical scavenging effects.

• Attenuation of Inflammation: Studies in preclinical models have shown that Dimethyl Sulfoxide can reduce swelling and inflammatory markers.

  • Study: Anti-inflammatory effects of DMSO

  • Research Concentration: Studies often apply topical DMSO at concentrations ranging from 50% to 90% (v/v).

Suggested Research Protocols:

• Antioxidant Assays: Include 0.5% – 1% Dimethyl Sulfoxide as a control or experimental condition in in vitroradical scavenging assays.

• Topical Anti-Inflammatory Models: Apply 50-90% Dimethyl Sulfoxide solutions topically in preclinical models of localized inflammation.

Best for: Studying mechanisms of oxidative stress, researching topical anti-inflammatory agents, and as a control in radical scavenging assays.

EliteBiogenix Quality & Safety Assurance

Quality: Our DMSO Solution is ≥99.9% pure and certified as anhydrous (<0.1% water). It is packaged in a sealed, amber glass bottle to prevent light degradation and absorption of atmospheric moisture, which can compromise its purity and effectiveness.

Safety Handling Protocol for Researchers:

• Personal Protective Equipment (PPE): Always wear nitrile gloves (Dimethyl Sulfoxide can penetrate many other glove types), safety goggles, and a lab coat when handling.

• Ventilation: Use in a well-ventilated area or a fume hood. Dimethyl Sulfoxide is odorless at high purity but can be absorbed through the lungs.

• Contamination Warning: Be acutely aware that Dimethyl Sulfoxide will carry any chemical it contacts on the skin directly into the bloodstream. Ensure all surfaces and gloves are clean and free of other research chemicals.

• Storage: Store at room temperature, tightly sealed, in a cool, dry place.

Why Researchers Trust EliteBiogenix

• Uncompromising Purity: Every batch is GC-tested and verified ≥99.9% pure. Certificates of Analysis are available upon request.

• Research-Specific Focus: Our products are designed, labeled, and sold for laboratory use only. We are a trusted partner for academic, institutional, and industrial research.

• USA Shipping & Support: Fast, discreet, and compliant shipping to research facilities across the United States.

• Bulk Discounts Available: Contact us for pricing on large-volume research projects and long-term study needs.

Order Laboratory-Grade Dimethyl Sulfoxide Solution (60ml) today from EliteBiogenix.com to enhance your research into solubility, transdermal delivery, and cellular processes.

Disclaimer: These materials are for laboratory research purposes only. They are not drugs, food additives, or for human/veterinary use. The information presented is a compilation of scientific studies and is for educational purposes within the research community. It is not medical advice. You must be 18 years of age or older to purchase. Handle with appropriate personal protective equipment and respect for its chemical properties.