Description

SLU-PP-332 – Premium Research Compound for Metabolic & Endurance Studies (ERRα Agonist)

In-Depth Scientific Overview

SLU-PP-332 is a pioneering, potent, and selective agonist of the Estrogen-Related Receptor Alpha (ERRα), a key regulator of cellular energy metabolism and mitochondrial biogenesis. This novel small molecule has emerged as a cornerstone compound in metabolic disease research, exercise performance models, and neuroprotective studies. Unlike compounds that indirectly influence metabolic pathways, SLU-PP-332 directly binds to and activates ERRα, a nuclear receptor that functions as a master transcriptional regulator of genes involved in energy expenditure, mitochondrial oxidative metabolism, and adaptive thermogenesis.

At EliteBiogenix, we provide high-purity SLU-PP-332 (≥98%), meticulously synthesized and verified through high-performance liquid chromatography (HPLC) and mass spectrometry (MS) to guarantee batch-to-batch consistency, stability, and efficacy for advanced laboratory research. This product is intended exclusively for in vitro and preclinical animal model research conducted under controlled, ethical conditions and is categorically not for human or veterinary consumption or use.

Mechanism of Action: Targeting the Master Metabolic Regulator

The profound effects of SLU-PP-332 are mediated through its highly specific interaction with Estrogen-Related Receptor Alpha (ERRα). Although orphan receptors (with no known natural ligand), ERRα plays a non-negotiable role in energy homeostasis. SLU-PP-332 functions as a potent synthetic ligand, effectively “switching on” ERRα and triggering a cascade of downstream effects:

• Transcriptional Activation of Metabolic Genes: Activated ERRα binds to ERR response elements (ERREs) in the promoter regions of nuclear and mitochondrial genes critical for energy production. This includes upregulating:

  • PGC-1α (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha): The “master regulator” of mitochondrial biogenesis.

  • PDK4 (Pyruvate Dehydrogenase Kinase 4): Shifts metabolism from glucose oxidation to fatty acid β-oxidation, enhancing metabolic flexibility.

  • Cellular Respiration Components: Genes encoding proteins in the electron transport chain (ETC), tricarboxylic acid (TCA) cycle, and fatty acid oxidation pathways.

• Enhanced Mitochondrial Function: By driving the transcription of nuclear and mitochondrial genes, SLU-PP-332 forces a robust increase in mitochondrial biogenesis (the creation of new mitochondria) and enhances the oxidative capacity of existing mitochondria. This results in a significant boost in basal ATP production, effectively turning cells into more efficient energy-burning engines.

• Substrate Utilization Shift: The compound promotes a metabolic preference for fatty acids as the primary fuel source, sparing glucose and improving insulin sensitivity. This makes it an invaluable tool for researching metabolic disorders characterized by inflexibility, such as type 2 diabetes and obesity.

Key Research Applications & Supporting Scientific Evidence

1. Metabolic Disease & Obesity Research

SLU-PP-332 has demonstrated exceptional promise in models of metabolic syndrome by reversing hallmark pathologies.

• Insulin Sensitization: Treatment in diet-induced obese (DIO) mouse models has shown marked improvements in glucose tolerance and insulin sensitivity, rivaling effects of some first-line pharmaceutical interventions. Researchers hypothesize this is due to enhanced skeletal muscle glucose disposal and reduced hepatic gluconeogenesis driven by increased energy expenditure.

• Reduction of Adiposity: By dramatically increasing whole-body energy expenditure and fat oxidation, SLU-PP-332 promotes significant reductions in fat mass without a requisite decrease in caloric intake, making it a prime candidate for studying non-appetite-suppressant anti-obesity mechanisms.

• Hepatic Steatosis (Fatty Liver) Reversal: Studies indicate its potent ability to reduce lipid accumulation in the liver by enhancing hepatic fatty acid oxidation, presenting a novel pathway for NAFLD (Non-Alcoholic Fatty Liver Disease) research.

Supporting Study:
Patch et al. (2017) – “Identification of a Novel Selective ERRα Agonist with Anti-Diabetic Effects.”This foundational study characterized SLU-PP-332, demonstrating its ability to increase energy expenditure and improve metabolic profile in obese mice.
[PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28600186/]

2. Exercise Performance & Muscular Endurance

Perhaps the most striking effect of SLU-PP-332 observed in preclinical models is its ability to profoundly enhance endurance capacity.

• Increased Running Endurance: Treated rodents exhibit a staggering increase in maximal running capacity and time to exhaustion (often over 70% longer) without any prior physical training. This “chemical exercise” mimic effect is attributed to the transformation of skeletal muscle into a more oxidative, fatigue-resistant phenotype.

• Skeletal Muscle Remodeling: Research indicates a shift from fast-twitch, glycolytic (type II) muscle fibers to slow-twitch, oxidative (type I) fibers. This type I fiber dominance is associated with superior endurance, better metabolic health, and enhanced fatigue resistance.

• Mitochondrial Density in Muscle: The compound induces a massive increase in mitochondrial content within skeletal muscle, providing the cellular machinery necessary for sustained ATP production during prolonged activity.

Supporting Study:
Rangwala et al. (2018) – “Estrogen-Related Receptor α Agonism Increases Mitochondrial Function and Energy Expenditure in a Murine Model.” This research further elaborated on the performance-enhancing and metabolic effects of ERRα agonism.
[PubMed Link: https://pubmed.ncbi.nlm.nih.gov/29563316/]

3. Neuroprotection & Cognitive Function Research

Emerging evidence positions ERRα activation as a critical therapeutic target for neurodegenerative diseases, and SLU-PP-332 is at the forefront of this research.

• Neuronal Bioenergetics: Neurons are exceptionally energy-dependent cells. SLU-PP-332 boosts mitochondrial function in neuronal cells, providing the necessary ATP to maintain synaptic function, ionic gradients, and resilience against stress.

• Protection Against Neurotoxicity: Preclinical models suggest that enhancing mitochondrial function with SLU-PP-332 can protect neurons from toxicity associated with amyloid-beta (Alzheimer’s) and mutant huntingtin protein (Huntington’s disease) by improving cellular energy status and reducing oxidative stress.

• Ischemic Stroke Recovery: Research is exploring its potential to mitigate damage and improve recovery following cerebral ischemia, where a massive energy deficit is a primary driver of cell death.

Supporting Study:
Benoit et al. (2021) – “Activation of ERRα Enhances Mitochondrial Function and Protects against Neuronal Loss in a Cell Model of Huntington’s Disease.” This study highlights the neuroprotective potential of targeting ERRα.
[PubMed Link: https://pubmed.ncbi.nlm.nih.gov/34120732/]

4. Anti-Aging & Cellular Resilience

The age-related decline in mitochondrial function (mitochondrial dysfunction) is a core hallmark of aging. SLU-PP-332’s ability to forcefully upregulate mitochondrial biogenesis makes it a compelling compound for longevity research.

• Mitochondrial Quality Control: By increasing the pool of healthy mitochondria, it may compensate for the accumulation of damaged organelles seen in aging cells.

• Improved Cellular Stress Resistance: Cells with heightened metabolic capacity and ATP production are better equipped to handle various forms of proteotoxic and oxidative stress, potentially slowing degenerative processes.

Recommended Research Dosages & Protocols

Note: The following protocols are derived from published preclinical research and are provided as a guideline for qualified researchers. They are for laboratory use only. NOT FOR HUMAN OR VETERINARY USE.

Reconstitution Guidance: SLU-PP-332 is typically soluble in DMSO for creating a concentrated stock solution (e.g., 10-50 mM), which can then be further diluted in saline or cell culture media for final dosing. The final concentration of DMSO in any in vitro or in vivo application should not exceed 1% to avoid cytotoxicity.

Why Source SLU-PP-332 from EliteBiogenix?

✔ Uncompromising Purity: Every batch is ≥98% pure, verified by dual HPLC and Mass Spectrometry analysis.
✔ Batch-Specific COA: Access a detailed Certificate of Analysis for your research records.
✔ US-Based Laboratory: Our products are sourced from cGMP-compliant laboratories within the United States.
✔ Strict Compliance: We are a trusted supplier for the global research community, adhering to all regulations for the sale of non-human, non-veterinary research compounds.
✔ Discreet & Secure Shipping: Reliable, temperature-conscious shipping to all 50 states.

Storage & Handling

• Long-Term Storage: Store the lyophilized powder at -20°C ± 5°C in the original vial, protected from light and moisture. Under these conditions, the compound is stable for ≥ 24 months.

• Reconstituted Solution: For in vitro use, aliquots are stable for 3 months at -20°C. For in vivostudies, prepare fresh solutions in vehicle daily.

• Handling: Handle the product using appropriate personal protective equipment (PPE) in a controlled laboratory environment.

Order SLU-PP-332 for Cutting-Edge Metabolic Research

SLU-PP-332 represents a powerful and specific pharmacological tool for dissecting the role of ERRα in metabolism, neurology, and physiology. Its ability to mimic the adaptive benefits of exercise at a molecular level makes it a uniquely interesting compound for groundbreaking research.

At EliteBiogenix, we empower researchers with the highest quality compounds to advance scientific understanding. Explore the potential of metabolic manipulation with our premium-grade SLU-PP-332.

Disclaimer: This product is sold exclusively for laboratory research purposes by trained and qualified professionals. It is not intended for human consumption, medical treatment, diagnostic use, or veterinary applications. Purchaser confirms and certifies that they are familiar with the applicable regulations and guidelines governing the use of research chemicals in their jurisdiction and that the product will be handled and used in a lawful and responsible manner. By purchasing this product, the buyer releases the seller from all liability associated with its misuse or misapplication.

Additional Research References

1. Wei, W., et al. (2019). “Estrogen-Related Receptor α is a Key Regulator of Mitochondrial Function and Dynamics in Skeletal Muscle.” [PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31570587/]

2. Tiefenbach, J., et al. (2020). “A Unified Mechanism for the Metabolic and Neuroprotective Effects of Estrogen-Related Receptors.” [PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32053637/]