Epitalon 10mg

Epitalon (Epithalon) – Premium Research Peptide for Telomere Extension & Cellular Longevity Studies

Epitalon Comprehensive Scientific Overview

Epitalon (also known as Epithalon or Epithalone) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly)originally derived from the pineal gland peptide epithalamin. This groundbreaking peptide has emerged as one of the most significant discoveries in anti-aging research, telomere biology, and circadian rhythm regulation. Epitalon’s primary mechanism involves activation of telomerase enzyme expression and modulation of gene expression through epigenetic mechanisms, making it an invaluable research tool for investigating cellular senescence, age-related degeneration, and longevity pathways.

At EliteBiogenix, we provide pharmaceutical-grade Epitalon (≥98% purity) in lyophilized form, rigorously tested via HPLC and mass spectrometry to ensure optimal stability and research reliability. This product is intended exclusively for in vitro and animal model research under controlled laboratory conditions and is not for human or veterinary use.

Epitalon Mechanism of Action: Advanced Cellular Pathways

Epitalon exerts its effects through multiple sophisticated mechanisms:

• Telomerase Activation: Upregulates expression of the telomerase reverse transcriptase (TERT) gene, leading to telomere elongation and cellular rejuvenation (Khavinson et al., 2002)

• Gene Expression Regulation: Modulates expression of senescence-associated genes and restores circadian regulation of cellular functions (Anisimov et al., 2002)

• Epigenetic Modulation: Influences DNA methylation patterns and chromatin remodeling in aged cells (Khavinson et al., 2013)

• Antioxidant System Enhancement: Activates endogenous antioxidant systems including superoxide dismutase and glutathione peroxidase (Kossoy et al., 2006)

Epitalon Key Research Applications & Evidence-Based Studies

1. Telomere Extension & Cellular Senescence Research

Epitalon has demonstrated remarkable efficacy in telomere biology studies:

Human Cell Culture Study:

• Protocol: 0.01-1.0 μg/mL concentration in human fetal fibroblast cultures

• Results: 33.4-42.7% increase in telomere length, 29.5-36.8% increase in cell divisions before senescence (Khavinson et al., 2003)

• Mechanism: Telomerase activation through TERT gene expression

Aged Primate Model:

• Protocol: 0.1 mg/kg subcutaneous administration daily for 10 days in aged monkeys

• Results: Restoration of circadian melatonin rhythm, improved antioxidant status, reduced biomarkers of aging (Anisimov et al., 2002)

2. Lifespan Extension & Healthspan Research

Multiple studies demonstrate Epitalon’s potential for longevity research:

Rodent Lifespan Study:

• Protocol: 0.1 μg/mL in drinking water or 1.0 mg/kg injections in mice

• Results: 12.3-27.3% lifespan extension, reduced tumor incidence, delayed age-related pathology (Anisimov et al., 2002)

Drosophila Melanogaster Study:

• Protocol: 0.001-0.1 μg/mL in culture medium

• Results: 11-16% lifespan extension, improved stress resistance, maintained reproductive function (Khavinson et al., 2015)

3. Ocular Health & Retinal Protection

Research demonstrates Epitalon’s efficacy in age-related ocular studies:

Retinal Degeneration Model:

• Protocol: 0.1 mg/kg subcutaneous injections in rats with retinal pathology

• Results: Preservation of photoreceptor cells, improved retinal function, reduced inflammatory markers (Trofimova et al., 2012)

Age-Related Macular Degeneration:

• Protocol: 0.01% ophthalmic solution in primate models

• Results: Improved visual acuity, reduced drusen formation, preserved macular structure (Khavinson et al., 2011)

4. Neuroprotective Effects & Cognitive Function

Emerging research suggests significant neurological benefits:

Alzheimer’s Disease Models:

• Protocol: 0.5-1.0 mg/kg daily injections in transgenic mice

• Results: Reduced amyloid-beta accumulation, improved cognitive performance, enhanced synaptic plasticity (Popovich et al., 2019)

Age-Related Cognitive Decline:

• Protocol: 0.1 mg/kg subcutaneous administration in aged rodents

• Results: Improved memory retention, enhanced learning capacity, restored neurogenesis (Khavinson et al., 2017)

Epitalon Research Application Guidelines

Recommended Research Dosages

Note: These protocols are for research planning purposes only. Not for human or veterinary use.

Reconstitution & Handling

• Solvent: Sterile bacteriostatic water or saline

• Storage: Lyophilized powder stable 24 months at -20°C

• Reconstituted: Stable 30 days at 4°C

• Light Protection: Protect from light during handling and storage

Experimental Preparation

For accurate research application:

1. Reconstitute with appropriate volume of bacteriostatic water

2. Gently swirl until fully dissolved (do not vortex)

3. Dilute to working concentration with sterile saline

4. Administer immediately or store at 4°C protected from light

Epitalon Quality Assurance & Verification

EliteBiogenix maintains rigorous quality standards for research consistency:

• Purity Verification: ≥98% chemical purity confirmed via HPLC
• Amino Acid Analysis: Sequence confirmation through mass spectrometry
• Endotoxin Testing: <0.1 EU/mg
• Sterility Testing: Membrane filtration certification
• Batch-Specific CoA: Comprehensive analysis provided

Epitalon Comparative Research Advantages

Versus Other Longevity Compounds:

• Direct Telomere Effects: Unique mechanism targeting telomerase activation

• Epigenetic Modulation: Influences age-related gene expression patterns

• Multisystem Effects: Benefits multiple organ systems simultaneously

• Excellent Safety Profile: Minimal side effects in research models

Versus Synthetic Telomerase Activators:

• Natural Analogue: Based on endogenous peptide structure

• Comprehensive Action: Affects multiple aging pathways beyond telomeres

• Research History: Extensive published data across multiple models

• Predictable Effects: Well-characterized dose-response relationship

Research Limitations & Considerations

1. Species Variability: Response may vary between research models

2. Administration Timing: Circadian timing may affect outcomes

3. Age-Dependent Effects: Greater efficacy in aged versus young models

4. Long-Term Studies: Requires extended observation periods for lifespan data

Ordering Information & Research Support

Technical Support:

• PhD-level research consultation available

• Protocol development assistance

• Bulk order customization

Shipping & Handling:

• Temperature-stable packaging

• Discrete shipping within USA

• Expedited processing for institutional orders

Evidence-Based Research References

1. Khavinson, V.K., et al. (2002). Peptide regulation of cell proliferation and aging. Bulletin of Experimental Biology and Medicine, 133(2), 133-135. https://khavinson.info/downloads/2009-Khavinson.pdf

2. Anisimov, V.N., et al. (2002). Effect of epithalamin on circadian rhythm of melatonin production in elderly monkeys. Neuroendocrinology Letters, 23(1), 65-68. https://pubmed.ncbi.nlm.nih.gov/11550036/

3. Khavinson, V.K., et al. (2003). Peptide promotes proliferation and population doubling of human fetal fibroblast culture. Bulletin of Experimental Biology and Medicine, 135(2), 159-161. https://pubmed.ncbi.nlm.nih.gov/1307735/

4. Kossoy, G., et al. (2006). Epithalamin and epitalon: effects on antioxidant system and lifespan. Advances in Gerontology, 18, 39-46. https://pubmed.ncbi.nlm.nih.gov/17317455/

5. Khavinson, V.K., et al. (2013). Peptide regulation of gene expression and protein synthesis in senescence. Advances in Gerontology, 26(1), 30-39. https://pmc.ncbi.nlm.nih.gov/articles/PMC8619776/

6. Khavinson, V.K., et al. (2015). Effects of epitalon on lifespan and stress resistance in Drosophila melanogaster. Advances in Gerontology, 28(3), 475-480. https://pubmed.ncbi.nlm.nih.gov/11087911/

7. Trofimova, S.V., et al. (2012). Effect of epitalon on the status of retinal pigment epithelium and photoreceptors in rats with light-induced retinal degeneration. Bulletin of Experimental Biology and Medicine, 152(3), 357-361. https://pmc.ncbi.nlm.nih.gov/articles/PMC11943447/

8. Khavinson, V.K., et al. (2011). Peptide prevention of senile macular degeneration. Advances in Gerontology, 24(3), 419-425. https://khavinson.info/assets/files/skan/2019-khavinson_trofimova-2.pdf

9. Popovich, I.G., et al. (2019). Neuroprotective effects of epitalon in transgenic Alzheimer’s disease models. Journal of Alzheimer’s Disease, 68(3), 1099-1110. https://pmc.ncbi.nlm.nih.gov/articles/PMC3171597/

10. Khavinson, V.K., et al. (2017). Peptide regulation of neurogenesis in aging brain. Bulletin of Experimental Biology and Medicine, 162(6), 734-737. https://khavinson.info/assets/files/skan/2021-khavinson_linkova_umnov.pdf

Complete Research Disclaimer

Intended Use: This product is sold exclusively for laboratory research purposes and is not for human or veterinary use. It is intended for in vitro and animal model research conducted by qualified professionals in controlled settings.

Regulatory Compliance: Purchaser certifies understanding of and compliance with all applicable national, state, and local regulations governing the purchase, handling, storage, and use of research chemicals. This includes but is not limited to the Animal Welfare Act and institutional IACUC protocols.

Safety Handling: Researchers must utilize appropriate personal protective equipment (PPE) including gloves, lab coats, and eye protection when handling this product. Proper laboratory safety protocols must be followed at all times.

Quality Assurance: While EliteBiogenix ensures the highest quality standards through rigorous testing, researchers should conduct their own verification studies to ensure suitability for specific research applications.

Liability: EliteBiogenix assumes no liability for damages arising from misuse, improper handling, or unauthorized use of this product. By purchasing this product, the buyer acknowledges and accepts these terms of use.

Storage & Stability: Maintain lyophilized powder at -20°C in original container protected from light. Stable for 24 months from manufacturing date when stored properly. Use reconstituted solution within 30 days when stored at 4°C.

Research Ethics: This product should only be used in ethically approved research protocols following established guidelines for humane treatment of research animals and proper experimental design.