Description

Aniracetam – 500mg x 60 Capsules – A Potent Racetam for Cognitive and Neurochemical Studies

Modulating Glutamatergic and Cholinergic Systems: A Research Guide to Aniracetam

Welcome, esteemed researchers, to EliteBiogenix’s detailed examination of a second-generation racetam compound: Aniracetam. This product is provided in a convenient, pre-measured capsule form, with each capsule containing 500mg of high-purity Aniracetam powder, and 60 capsules per bottle. This format ensures precise, consistent unit-dosing for analytical and ex-vivo research applications, eliminating the need for repetitive weighing and reducing cross-contamination risks. Aniracetam (1-p-anisoyl-2-pyrrolidinone) is a fat-soluble compound known for its potent neuromodulatory effects, primarily influencing the cholinergic and glutamatergic systems. This product description serves as a foundational research primer to guide your experimental design in neuropharmacology and cognitive science.

Section 1: The Scientific Basis of Aniracetam’s Mechanism of Action

Aniracetam’s research value lies in its unique ability to positively modulate key neurotransmitter systems involved in learning, memory, and synaptic plasticity. Its mechanisms are more complex and potent than its predecessor, Piracetam.

1. Positive Allosteric Modulation of AMPA Receptors: A primary mechanism of Aniracetam is its action as a positive allosteric modulator of the AMPA-type glutamate receptors. AMPA receptors are crucial for fast excitatory synaptic transmission in the brain. By binding to an allosteric site on the receptor, Aniracetam slows the rate of receptor desensitization and deactivation. This results in a more prolonged and enhanced postsynaptic response to glutamate, facilitating synaptic plasticity, which is the cellular correlate of learning and memory. This AMPAkine-like property is a major focus of research into cognitive enhancement and neuronal signaling.

2. Interaction with Cholinergic Systems: Aniracetam has been shown to modulate cholinergic neurotransmission, albeit indirectly. Research suggests it can increase the release of acetylcholine (ACh) in certain brain regions, such as the hippocampus and cortex. Furthermore, it may influence muscarinic cholinergic receptors. This cholinergic activity is thought to synergize with its glutamatergic effects, making it a valuable compound for studying the interplay between these two critical systems in cognitive processes.

3. Modulation of Other Neurotransmitter Systems: Evidence from preclinical models indicates that Aniracetam can also affect other systems. It has been reported to increase the release of dopamine and serotonin in the frontal cortex and hippocampus, which may contribute to its observed effects on mood and motivation in animal models. This broad neuromodulatory profile makes it a useful tool for researching complex neurochemical networks.

4. Potential Neuroprotective and Anxiolytic Properties: Some studies suggest that by enhancing metabolic activity and modulating excitatory transmission, Aniracetam may offer protective benefits in models of oxidative stress and neuronal hypoxia. Its metabolites are also investigated for potential anxiolytic-like effects in behavioral models, providing a multi-faceted research profile.

The multi-modal action of Aniracetam makes it a versatile tool for researchers investigating the integrated neurobiology of cognition, affect, and neuronal resilience.

Section 2: Key Research Applications for Aniracetam

Our bottle of 60 x 500mg capsules is designed for controlled laboratory research. The capsule contents can be precisely emptied for use in in-vitro studies or for the preparation of solutions for ex-vivo analysis. The following sections outline primary research domains, supported by peer-reviewed studies.

2.1 Investigating Synaptic Plasticity and AMPA Receptor Function

The enhancement of AMPA receptor function is a leading hypothesis for it’s procognitive effects, making it a key compound for studying synaptic plasticity.

• Relevant Study: *Ito, I., Tanabe, S., Kohda, A., & Sugiyama, H. (1990). Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. The Journal of Physiology, 424(1), 533-543.*

  • PubMed Link: https://pubmed.ncbi.nlm.nih.gov/1974920/

  • Focus of Research: This foundational in-vitro electrophysiological study examined the direct effects of Aniracetam on glutamate receptors in cultured hippocampal neurons.

  • Key Findings: The research demonstrated that Aniracetam potently and selectively potentiates the current through AMPA-type glutamate receptors, slowing the decay of the excitatory postsynaptic current (EPSC). This provided direct mechanistic evidence for its action as a cognitive enhancer by facilitating synaptic transmission.

  • Research Implication: Researchers can use the contents of our capsules to create stock solutions for application in neuronal cell cultures or brain slice preparations. Electrophysiological techniques (patch-clamp) can be used to measure the potentiation of AMPA receptor-mediated currents and the effects on Long-Term Potentiation (LTP), a direct measure of synaptic strength.

  • Estimated Compound Usage for In-Vitro Replication: This and similar electrophysiology studies use Aniracetam at concentrations typically between 1-5 mM in the perfusion solution. A single 500mg capsule, dissolved to create a 100 mM stock solution, can be diluted to prepare liters of physiological saline for such experiments. One capsule can therefore supply a significant volume of research material.

2.2 Research on Cognitive Enhancement and Memory Models

Aniracetam has been extensively studied in animal models of learning and memory, particularly in situations of cognitive deficit.

• Relevant Study: *Cumin, R., Bandle, E. F., Gamzu, E., & Haefely, W. E. (1982). Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents. Psychopharmacology, 78(2), 104-111.*

  • PubMed Link: https://pubmed.ncbi.nlm.nih.gov/6818588/

  • Focus of Research: This early preclinical study investigated the effects of Aniracetam on memory deficits induced in rodents by scopolamine (a cholinergic antagonist) or electroconvulsive shock.

  • Key Findings: Aniracetam administration was shown to reverse the amnesic effects of both scopolamine and electroconvulsive shock in passive avoidance and maze-learning tasks. This highlighted its potential to ameliorate cognitive impairments caused by different mechanisms.

  • Research Implication: For in-vitro research, this translates to using our Aniracetam in models of cholinergic deficiency (e.g., treating neuronal cultures with scopolamine) or metabolic stress. Researchers can then assess if co-administration of Aniracetam can restore markers of neuronal health, synaptic protein expression (e.g., PSD-95, synaptophysin), or network activity measured by microelectrode array (MEA).

  • Estimated Compound Usage for In-Vitro Replication: Cell culture studies often use effective concentrations in the range of 10-100 µM. The 60-capsule supply (30 grams total) provides a massive quantity of material for extensive, long-term cell culture studies, high-throughput screening, and method development.

2.3 Exploring Anxiolytic and Anti-Stress Effects

Beyond cognition, Aniracetam’s metabolite profile has been linked to effects on anxiety-like behaviors in animal models, providing a research avenue into mood and stress.

• Relevant Study: *Shimizu, S., Honda, M., Tanabe, Y., & Ono, H. (1998). Aniracetam augments, and midazolam inhibits, the long-term potentiation in guinea-pig hippocampal slices. Neuroscience Letters, 249(2-3), 91-94.*

  • PubMed Link: https://pubmed.ncbi.nlm.nih.gov/9682830/

  • Focus of Research: While focused on LTP, this study touches on the contrast between a cognitive enhancer (Aniracetam) and an anxiolytic (midazolam). Other studies have directly investigated Aniracetam’s anxiolytic potential.

  • Key Findings: Research in validated anxiety models (e.g., Vogel conflict test, elevated plus maze) has shown that Aniracetam and its metabolites can produce anxiolytic-like effects without the sedative properties of benzodiazepines.

  • Research Implication: Researchers can use our Aniracetam in in-vitro models of neuronal stress and anxiety. This could involve treating neuronal or glial cell cultures with corticosterone to model physiological stress and then measuring the expression of stress-related genes, inflammatory cytokines, or neuronal hyperexcitability, with and without Aniracetam co-treatment.

  • Estimated Compound Usage for In-Vitro Replication: Stress and inflammation models may require sustained exposure over days. The large supply of 60 capsules ensures that researchers can maintain chronic dosing regimens in their culture systems without concern for running out of material.

2.4 Studies on Age-Related Cognitive Decline and Neuroprotection

The combined glutamatergic and cholinergic support offered by Aniracetam makes it a candidate for research into age-related neurological conditions.

• Research Application: Cell culture models of aging, such as senescent neuronal cells or models of amyloid-beta toxicity, can be used to test if Aniracetam can protect against synaptic loss, reduce oxidative stress, or improve resilience in aged neuronal networks.

• Experimental Design: Researchers can treat aged primary neurons or relevant cell lines with the contents of our Aniracetam capsules. Endpoints could include cell viability assays, measurements of reactive oxygen species (ROS), mitochondrial function, and assessments of synaptic density via immunocytochemistry.

Section 3: Synergistic Research: Aniracetam and Other Compounds

A sophisticated research approach often involves studying combinations of compounds to explore synergistic effects on cognitive and neurochemical pathways.

• With Cholinergic Compounds (e.g., Alpha GPC): This is a classic research stack. The hypothesis is that Aniracetam modulates AMPA and cholinergic receptors, while a choline donor like Alpha GPC provides the precursor for acetylcholine synthesis. In-vitro research can test if this combination leads to a synergistic increase in ACh release or enhanced neuronal network activity compared to either compound alone.

• With Other Racetams: Research can be designed to compare the potency and efficacy of Aniracetam with other racetams (e.g., Piracetam, Oxiracetam) in the same experimental model, providing valuable comparative pharmacological data.

• With Neuroprotective Peptides: Studies could investigate if Aniracetam can enhance the effects of peptides like Cerebrolysin or BPC-157 in models of neuronal injury, by providing complementary support for synaptic function and cellular resilience.

Section 4: EliteBiogenix Quality and Specifications

Product Specification:

• Compound Name: Aniracetam (1-p-anisoyl-2-pyrrolidinone)

• Amount per Capsule: 500mg

• Capsule Count: 60

• Total Aniracetam: 30,000mg (30 grams)

• Capsule Shell: Hypromellose (Vegetarian Cellulose) or similar inert material.

• Purity: ≥98% (HPLC Verified)

• Form: Powder in capsule

• Storage: Store in a cool, dry place. Protect from light and moisture. Keep desiccant in bottle.

• Handling: For laboratory use only. Capsule contents must be emptied under controlled conditions for research. The capsule shell is an inert vehicle and is not for consumption.

Why Choose EliteBiogenix for Your Aniracetam Research?

• Pre-Measured Precision: The capsule format provides a precise, consistent 500mg unit dose, eliminating weighing errors and saving valuable time in the lab.

• Analytical Convenience: The powder-in-capsule format is ideal for researchers who need to run analytical tests (HPLC, MS) on a standardized sample or for preparing stock solutions of exact concentration.

• Uncompromising Purity: Every batch is independently verified via HPLC to ensure you are working with a high-purity compound, free from significant contaminants.

• High-Volume Supply: With 30 grams total, this product supports long-term research projects, extensive dose-response studies, and method development without the need for frequent reordering.

• Research-Focused: We cater exclusively to the scientific community. Our products and documentation are designed for laboratory use, providing the data and quality required for rigorous scientific investigation.

Section 5: Conclusion and Research Direction

This bottle of 60 x 500mg Aniracetam capsules from EliteBiogenix provides a versatile and potent tool for advanced research in neuroscience. Its multi-modal action on AMPA receptors and cholinergic systems makes it an invaluable compound for dissecting the mechanisms of synaptic plasticity, cognitive function, and neuronal protection. Research with Aniracetam continues to illuminate the fundamental processes of learning, memory, and brain resilience.

We are committed to supporting your important work with the highest quality, most convenient research materials available.

Order your bottle of Aniracetam (500mg x 60 Capsules) today and advance your research into glutamatergic and cholinergic signaling.

Remember: EliteBiogenix.com products are for laboratory research use only. Not for human or veterinary consumption. The capsule form is for analytical convenience and must not be ingested.