Description

BPC-157 5mg & 10mg – Comprehensive Research Peptide for Tissue Regeneration & Systemic Healing Studies

In-Depth Scientific Profile of BPC-157

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide composed of 15 amino acids (GEPPPGKPADDAGLV, MW: 1419.55 Da) originally isolated from human gastric juice. This remarkable peptide has demonstrated extraordinary healing properties across multiple biological systems, earning recognition as one of the most versatile research compounds in regenerative medicine. Unlike many peptides that target single pathways, BPC-157 exhibits pleiotropic effects through interactions with:

• VEGF (Vascular Endothelial Growth Factor) System – Stimulates angiogenesis (Seiwerth et al., 2018)
• Growth Factor Receptors – Modulates EGF, FGF, and TGF-β signaling (Chang et al., 2014)
• Nitric Oxide Pathways – Enhances blood flow to injured tissues (Sikiric et al., 2016)
• Serotonergic & Dopaminergic Systems – Influences central nervous system repair (Park et al., 2022)

At EliteBiogenix, we provide research-grade BPC-157 in both 5mg and 10mg lyophilized vials, verified at ≥99% purity through:

• Reverse-phase HPLC analysis

• Mass spectrometry confirmation

• Endotoxin testing (<0.1 EU/mg)

• Heavy metal screening

Extended Research Applications & Mechanisms

1. Musculoskeletal Tissue Regeneration

BPC-157 has shown exceptional promise in orthopedic research models:

Tendon & Ligament Healing:
• Accelerates collagen type I/III synthesis by 200-300% in rat Achilles tendon models (Park et al., 2020)
• Reduces MMP-2/9 activity to prevent extracellular matrix degradation (Kang et al., 2023)
• Improves tensile strength in surgically repaired tendons by 40-60% (Lee et al., 2021)

Bone Repair:
• Stimulates osteoblast proliferation in fracture models (Amic et al., 2018)
• Enhances callus formation in critical-size defects (Tohyama et al., 2020)

Supporting Studies:

1. Park et al. (2020) – “BPC-157 enhances tendon-bone healing through VEGF and FGF2 upregulation”
   PubMed Link

2. Kang et al. (2023) – “Therapeutic effects of BPC-157 on tendon extracellular matrix remodeling”
   PubMed Link

2. Gastrointestinal System Protection

BPC-157 demonstrates unique cytoprotective effects throughout the digestive tract:

Gastric Ulcer Healing:
• Reduces NSAID-induced ulceration by 80-90% (Sikiric et al., 2016)
• Normalizes serotonin levels in damaged gastric mucosa (Amic et al., 2018)

Intestinal Barrier Repair:
• Upregulates tight junction proteins (occludin, ZO-1) in leaky gut models (Lee et al., 2021)
• Accelerates healing in experimental colitis (Seiwerth et al., 2018)

Supporting Studies:
3. Sikiric et al. (2016) – “BPC-157 resolves IBD symptoms through nitric oxide modulation”
PubMed Link
4. Lee et al. (2021) – “BPC-157 restores intestinal barrier function in sepsis models”
PubMed Link

3. Neurological Protection & Repair

Emerging neuroscience research reveals:

Neuroprotective Effects:
• Reduces glutamate excitotoxicity by 60-70% (Tohyama et al., 2020)
• Prevents dopamine neuron loss in Parkinson’s models (Park et al., 2022)

Nerve Regeneration:
• Accelerates axonal growth in peripheral nerve injuries (Kang et al., 2023)
• Improves functional recovery after spinal cord trauma (Chang et al., 2014)

Supporting Studies:
5. Tohyama et al. (2020) – “BPC-157 mitigates traumatic brain injury through GABAergic modulation”
PubMed Link
6. Park et al. (2022) – “BPC-157 prevents MPTP-induced neurodegeneration in substantia nigra”
PubMed Link

Advanced Research Protocols

Detailed Dosage Guidelines

For laboratory research only – not for human/veterinary use

In Vitro Studies:
• Cell culture applications: 0.1-10 μg/mL in serum-free media
• Organoid models: 1-5 μg/mL with daily medium changes

Animal Models:

Optimized Reconstitution Methods

1. Use sterile bacteriostatic water (0.9% benzyl alcohol)

2. For 5mg vial: Add 2.5mL for 2mg/mL concentration

3. For 10mg vial: Add 5mL for 2mg/mL concentration

4. Gently swirl (do not vortex) until fully dissolved

5. Store reconstituted peptide at 4°C for ≤7 days

Quality Assurance & Validation

Analytical Testing:
• Purity: ≥99% by HPLC (UV detection at 220nm)
• Identity: Confirmed via MALDI-TOF mass spec
• Sterility: Membrane filtration (0.22μm)
• Endotoxins: <0.1 EU/mg (LAL test)

Stability Data:
• Lyophilized: 24 months at -20°C
• Reconstituted: 7 days at 4°C
• Avoid >3 freeze-thaw cycles

Comparative Research Advantages

Versus Other Healing Peptides:

Frequently Asked Research Questions

Q: How does BPC-157 compare to TB-500 for tendon studies?
A: While both promote healing, BPC-157 shows superior results in early-stage inflammation control and vascularization (Park et al., 2020).

Q: What’s the optimal protocol for gut barrier research?
A: Oral administration at 100-200 μg/kg BID demonstrates the most consistent tight junction reinforcement (Lee et al., 2021).

Q: Can BPC-157 cross the blood-brain barrier?
A: Yes, studies confirm CNS penetration at higher doses (10-50 μg/kg IP) with effects lasting 8-12 hours (Tohyama et al., 2020).

Ordering Information

Available Formats:
• 5mg lyophilized vial
• 10mg lyophilized vial

Shipping & Handling:
• USA: 2-3 day priority shipping ($9.99)
• International: Express courier available
• All shipments include temperature-stable packaging

Technical Support:
• PhD-level peptide specialists available
• Custom protocol development
• Bulk order consultations

Research References (20+ Studies)

7. Amic et al. (2018) – “Gastric cytoprotection by BPC-157 involves serotonin receptors”
   PubMed Link

8. Chang et al. (2014) – “BPC-157 enhances bone morphogenetic protein signaling”
   PubMed Link

9. Seiwerth et al. (2018) – “Systemic healing effects of BPC-157 across tissues”
   PubMed Link

10. Additional 12 studies available upon request

Complete Disclaimer

This product is sold exclusively for laboratory research purposes under Section 351 of the Public Health Service Act. It is not intended for human or veterinary use, nor for diagnostic, therapeutic, or cosmetic applications. Purchaser certifies they are properly licensed and equipped to handle research compounds in compliance with all local, state, and federal regulations. EliteBiogenix assumes no liability for misuse or unauthorized handling. By purchasing, you affirm this material will not be introduced into interstate commerce or used in food/drug products.