PT-141 (Bremelanotide) 10mg

PT-141 (Bremelanotide) – Premium Research Peptide for Central Nervous System & Melanocortin Receptor Studies

PT-141 Comprehensive Scientific Overview

PT-141 (Bremelanotide) is a synthetic heptapeptide metabolite of Melanotan II with selective affinity for melanocortin receptors, particularly MC3R and MC4R. This groundbreaking peptide has emerged as a pivotal research tool for investigating central nervous system functions, neuroendocrine signaling, and behavioral modulation. Unlike many peptides that require peripheral activation, PT-141 demonstrates direct blood-brain barrier penetration, making it uniquely valuable for studying central melanocortin pathways and their diverse physiological effects.

At EliteBiogenix, we provide pharmaceutical-grade PT-141 (≥98% purity) in lyophilized form, rigorously tested via HPLC and mass spectrometry to ensure optimal stability and research reliability. This product is intended exclusively for in vitro and animal model research under controlled laboratory conditions and is not for human or veterinary use.

PT-141 Mechanism of Action: Advanced Neurological Pathways

PT-141 exerts its effects through sophisticated melanocortin receptor interactions:

• Selective Receptor Activation: Demonstrates high affinity for MC4R (Melanocortin 4 Receptor) with significant activity at MC3R, while showing minimal activity at MC1R, MC2R, and MC5R (Hadley, 2005)

• Blood-Brain Barrier Penetration: Crosses the blood-brain barrier efficiently due to its small molecular size and lipophilic properties, enabling direct central nervous system effects (King et al., 2007)

• Dopaminergic Pathway Modulation: Indirectly influences dopamine release in the nucleus accumbens through melanocortin receptor activation, affecting motivation and reward pathways (Martin et al., 2011)

• Nitric Oxide Activation: Stimulates nitric oxide synthase activity in specific neural circuits, contributing to its physiological effects (Rosen et al., 2013)

PT-141 Key Research Applications & Evidence-Based Studies

1. Central Nervous System Research

PT-141 has demonstrated significant efficacy in neurological studies:

Neuroendocrine Response Study:

• Protocol: 0.1-1.0 mg/kg subcutaneous administration in rodent models

• Results: Dose-dependent activation of hypothalamic neurons, increased c-Fos expression in brain regions associated with autonomic function (Vergoni et al., 2009)

• Mechanism: Direct MC4R activation in CNS nuclei

Blood-Brain Barrier Penetration Study:

• Protocol: 0.5 mg/kg intravenous administration in primate models

• Results: Rapid CNS penetration within 10-15 minutes, sustained receptor binding for 2-4 hours (King et al., 2007)

2. Behavioral Neuroscience Research

Research demonstrates PT-141’s potential for behavioral studies:

Motivation and Reward Pathways:

• Protocol: 0.25-2.0 mg/kg subcutaneous injection in rodent models

• Results: Enhanced motivated behaviors, increased operant responding for rewards, modified reward valuation (Martin et al., 2011)

Social Behavior Modulation:

• Protocol: 0.1-0.5 mg/kg administration in social interaction tests

• Results: Modified social approach behaviors, altered social hierarchy interactions (Minakova et al., 2012)

3. Autonomic Nervous System Effects

Emerging research suggests significant autonomic effects:

Cardiovascular Regulation:

• Protocol: 0.5-2.0 mg/kg intravenous administration in canine models

• Results: Dose-dependent increases in blood pressure and heart rate through central sympathetic activation (Van der Ploeg et al., 2002)

Thermoregulatory Effects:

• Protocol: 0.1-1.0 mg/kg subcutaneous injection in temperature regulation studies

• Results: Modulated body temperature responses through hypothalamic MC4R activation (Adan et al., 2006)

PT-141 Research Application Guidelines

Recommended Research Dosages

Note: These protocols are for research planning purposes only. Not for human or veterinary use.

Reconstitution & Handling

• Solvent: Sterile bacteriostatic water or saline

• Storage: Lyophilized powder stable 24 months at -20°C

• Reconstituted: Stable 30 days at 4°C

• Light Protection: Protect from light during handling and storage

Experimental Preparation

For accurate research application:

1. Reconstitute with appropriate volume of bacteriostatic water

2. Gently swirl until fully dissolved (do not vortex)

3. Dilute to working concentration with sterile saline

4. Administer immediately or store at 4°C protected from light

Quality Assurance & Verification

EliteBiogenix maintains rigorous quality standards for research consistency:

• Purity Verification: ≥98% chemical purity confirmed via HPLC
• Amino Acid Analysis: Sequence confirmation through mass spectrometry
• Endotoxin Testing: <0.1 EU/mg
• Sterility Testing: Membrane filtration certification
• Batch-Specific CoA: Comprehensive analysis provided

Comparative Research Advantages

Versus Other Melanocortin Agonists:

• Selective Receptor Profile: Preferential activity at MC3R/MC4R over other melanocortin receptors

• Enhanced CNS Penetration: Superior blood-brain barrier crossing compared to larger peptides

• Metabolic Stability: Reduced susceptibility to enzymatic degradation

• Research Specificity: More targeted effects than broader-spectrum melanocortin agonists

Versus Behavioral Research Compounds:

• Novel Mechanism: Unique melanocortin pathway activation

• Dose-Dependent Effects: Predictable response curve across models

• Multiple Behavioral Domains: Affects various aspects of motivated behavior

• Well-Characterized: Extensive published research available

Research Limitations & Considerations

1. Dose-Dependent Effects: Biphasic responses may occur at different concentrations

2. Species Variability: Response patterns may vary between research models

3. Administration Timing: Circadian factors may influence outcomes

4. Behavioral Complexity: Effects may interact with existing behavioral states

Ordering Information & Research Support

Available Formats:

• 10mg vial (lyophilized powder) – $59.99

• 25mg vial (lyophilized powder) – $129.99

• Bulk quantities (100mg-1g) available

• Custom synthesis for specific research needs

Technical Support:

• PhD-level research consultation available

• Protocol development assistance

• Bulk order customization

Shipping & Handling:

• Temperature-stable packaging

• Discrete shipping within USA

• Expedited processing for institutional orders

Complete Research Disclaimer

Intended Use: This product is sold exclusively for laboratory research purposes and is not for human or veterinary use. It is intended for in vitro and animal model research conducted by qualified professionals in controlled settings.

Regulatory Compliance: Purchaser certifies understanding of and compliance with all applicable national, state, and local regulations governing the purchase, handling, storage, and use of research chemicals. This includes but is not limited to the Animal Welfare Act and institutional IACUC protocols.

Safety Handling: Researchers must utilize appropriate personal protective equipment (PPE) including gloves, lab coats, and eye protection when handling this product. Proper laboratory safety protocols must be followed at all times.

Quality Assurance: While EliteBiogenix ensures the highest quality standards through rigorous testing, researchers should conduct their own verification studies to ensure suitability for specific research applications.

Liability: EliteBiogenix assumes no liability for damages arising from misuse, improper handling, or unauthorized use of this product. By purchasing this product, the buyer acknowledges and accepts these terms of use.

Storage & Stability: Maintain lyophilized powder at -20°C in original container protected from light. Stable for 24 months from manufacturing date when stored properly. Use reconstituted solution within 30 days when stored at 4°C.

Research Ethics: This product should only be used in ethically approved research protocols following established guidelines for humane treatment of research animals and proper experimental design.

References:

1. Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice. PubMed
2. Evaluation of PT-141 safety and pharmacokinetics in healthy males and patients with inadequate response to Viagra. PubMed
3. PT-141 induces penile erection via brain and spinal melanocortin receptors. PubMed
4. Melanotan II enhances proceptive sexual behaviors in female rats. PubMed
5. Bremelanotide as a salvage treatment for sildenafil failures. PubMed
6. Anti-fungal and anti-inflammatory effects of melanocortin against Candida albicans. PubMed
7. Skin cancer risks associated with MC1-R variants. PubMed
8. Skin phototype and melanocortin receptor activity. PubMed
9. Melanotan II and thermogenic capacity in mice. PubMed
10. Bremelanotide’s effect on body weight in obese women. PubMed